Teaching methods
- 51 hrs lecture
- 21 hrs problem session
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Pre-requisites
SRM1, SRM2, SRM3, synthesis concepts 2, organic chemistry 1.
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Objectives
This is an elective which forms a logical extension of the organic chemistry courses of the first two years (e.g. synthesis concepts 2, organic chemistry 1). In addition, it offers some insight in the different areas of organic chemistry that are covered by the organic chemistry research groups.
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Contents
The course will consist of three separate parts: Fysical organic chemistry - general fysical organic topics: Free energy relations, Hammett-relation, isotope effects, acid/base catalysis
- host-guest chemistry
- supramolecular materials
- self-assembly
Peptide- and protein chemistry: Construction and modification of peptides and proteins will be discussed, involving the following topics: - protecting groups
- solution phase synthesis
- solid phase synthesis
- ligation methods
- synthesis strategy
Stereoselective synthesis - Stereoselective synthesis of olefins (eg. Wittig reaction, olefin metathesis)
- Stereoselective addition reactions onto electron-deficient alkenes (eg. conjugate addition)
- Diastereoselective additions onto carbonyl compounds
- Stereoselectivity in concerted reactions (cycloadditions, sigmatropic rearrangements)
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Examination
Schriftelijk tentamen.
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Literature
- Clayden, Greeves, Warren, Wothers, Organic Chemistry, Oxford University Press (2001); ISBN 0198503466
- handouts
- Anslyn, Dougherty, Modern Physical Organic Chemistry, University Science Books (2006); ISBN 1891389319 (optional).
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